Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 115 120.27 80.12 38,589,715
Mutual Fund 124 11.61 11.69 5,628,240
Insider 7 2.17 0.77 372,179

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 55 9.52 6.39 3,079,376
Sellers 60 -16.08 9.03 -4,350,442
Net -- -6.56 2.64 -1,271,066

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 120.27 80.12 38,589,715
Top 10 Inst. 92.06 63.07 30,375,540
Top 20 Inst. 107.77 72.52 34,929,382
Top 50 Inst. 117.94 78.67 37,889,990

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth 14 3.88 2.34 1,125,583
Aggressive Growth 1 0.76 0.46 221,192
Core Growth 11 3.03 1.83 879,697
Growth 2 0.09 0.05 24,694
Income 4 0.79 0.47 227,620
Income Value 3 0.49 0.30 142,385
Yield 1 0.29 0.18 85,235
Index 16 17.33 10.44 5,026,467
Other 47 94.36 64.41 31,024,239
Broker Dealer 12 1.40 0.84 404,927
GARP 8 5.28 3.18 1,530,809
Hedge Fund 20 25.77 21.79 10,496,567
Specialty 1 0.01 0.01 4,576
VC/Private Equi 6 61.91 38.59 18,587,360
Value 9 1.19 0.68 327,410
Core Value 8 0.78 0.44 209,616
Deep Value 1 0.41 0.24 117,794

Top Holders

Holder Shares Held % O/S Share Change Filing Date
The Column Group LP 6,642,942 13.79 800,000 3/28/18
Topspin Partners, LP 5,664,739 11.76 138,225 3/28/18
BVF Partners L.P. 5,231,353 10.86 573,000 10/16/18
Alta Partners 2,482,775 5.15 -- 3/28/18
EcoR1 Capital, LLC 2,241,900 4.65 -2,195,700 9/30/18
Versant Ventures 2,208,210 4.58 -- 9/30/18
BlackRock Institutional Trust Company, N.A. 1,911,841 3.97 24,012 9/30/18
The Vanguard Group, Inc. 1,615,442 3.35 11,006 9/30/18
ProQuest Investments 1,236,394 2.57 -- 9/30/18
Bain Capital Public Equity, LP 1,139,944 2.37 -81,424 9/30/18
Portolan Capital Management, L.L.C. 726,086 1.51 281,211 9/30/18
Dimensional Fund Advisors, L.P. 661,961 1.37 214,935 9/30/18
State Street Global Advisors (US) 552,534 1.15 86,375 9/30/18
Fidelity Management & Research Company 465,257 0.97 -719,235 9/30/18
JP Morgan Asset Management 390,100 0.81 -5,900 9/30/18
PanAgora Asset Management Inc. 384,622 0.80 -23,445 9/30/18
Abingworth Management Limited 352,300 0.73 -- 9/30/18
Geode Capital Management, L.L.C. 351,915 0.73 17,444 9/30/18
Northern Trust Investments, Inc. 340,567 0.71 3,832 9/30/18
Dafna Capital Management, LLC 328,500 0.68 -- 9/30/18
Two Sigma Investments, LP 300,319 0.62 42,805 9/30/18
Nuveen LLC 228,084 0.47 -4,259 9/30/18
Bridgeway Capital Management, Inc. 221,192 0.46 139,900 9/30/18
Coleman (Lewis W) 178,000 0.37 135,000 3/28/18
PNC Capital Advisors, LLC 153,901 0.32 153,901 11/30/17
Renaissance Technologies LLC 147,214 0.31 147,214 9/30/18
Guthart (Leo A) 138,225 0.29 127,500 12/31/17
Wells Fargo Advisors 133,835 0.28 -3,447 9/30/18
BlackRock Investment Management, LLC 117,794 0.24 1,611 9/30/18
Morgan Stanley & Co. LLC 105,249 0.22 32,672 9/30/18
D. E. Shaw & Co., L.P. 101,947 0.21 83,777 9/30/18
BNY Mellon Asset Management 91,061 0.19 6,873 9/30/18
Alps Advisors, Inc. 85,235 0.18 15,400 9/30/18
DRW Securities, LLC 80,000 0.17 21,100 9/30/18
Telemetry Investments, L.L.C. 79,555 0.17 -33,945 9/30/18
Deutsche Asset Management Americas 78,682 0.16 36,018 9/30/18
Baltimore (David) 78,287 0.16 -- 3/28/18
Berger (Franklin M) 75,000 0.16 -- 3/28/18
Goldman Sachs & Company, Inc. 64,144 0.13 24,559 9/30/18
BlackRock Financial Management, Inc. 63,071 0.13 -53,727 9/30/18
Charles Schwab Investment Management, Inc. 62,943 0.13 8,500 9/30/18
Yurasov (Sergey) 57,278 0.12 29,953 11/7/18
California State Teachers Retirement System 51,579 0.11 -- 9/30/18
Nexthera Capital LP 42,304 0.09 42,304 9/30/18
BNY Mellon Asset Management North America Corporation 41,397 0.09 -- 9/30/18
Cold Creek Capital, Inc 39,085 0.08 7,120 8/31/18
Brady (Stephen R) 38,365 0.08 29,953 11/7/18
Crow Point Partners, LLC 38,324 0.08 2,933 9/30/18
T. Rowe Price Associates, Inc. 35,252 0.07 207 9/30/18
Rhumbline Advisers Ltd. Partnership 33,286 0.07 -225 9/30/18

* Insider values reflect direct beneficial ownership.

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