Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 99 60.15 57.17 27,648,625
Mutual Fund 113 24.60 10.05 4,861,276
Insider 1 0.49 0.08 40,000

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 45 7.42 5.94 2,874,335
Sellers 49 -80.54 34.50 -16,687,090
Net -- -73.12 28.56 -13,812,755

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 60.15 57.17 27,648,625
Top 10 Inst. 46.87 44.40 21,473,638
Top 20 Inst. 54.49 51.87 25,089,167
Top 50 Inst. 58.98 56.25 27,203,258

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth 15 1.33 2.09 1,010,325
Aggressive Growth 1 0.06 0.09 42,400
Core Growth 13 1.25 1.96 945,737
Growth 1 0.03 0.05 22,188
Income 1 0.18 0.29 139,609
Income Value 1 0.18 0.29 139,609
Index 16 5.48 8.58 4,152,042
Other 37 49.49 44.09 21,325,556
Broker Dealer 12 0.84 1.11 535,050
GARP 7 1.46 2.32 1,122,333
Hedge Fund 12 6.82 6.75 3,266,852
Specialty 1 0.13 0.05 22,171
VC/Private Equi 5 40.25 33.87 16,379,150
Value 11 1.26 0.85 412,647
Core Value 8 1.05 0.52 251,000
Deep Value 3 0.21 0.33 161,647

Top Holders

Holder Shares Held % O/S Share Change Filing Date
The Column Group LP 6,642,942 13.73 -- 12/31/18
Topspin Partners, LP 5,664,739 11.71 138,225 3/28/18
Alta Partners 2,482,775 5.13 -- 3/28/18
BlackRock Institutional Trust Company, N.A. 1,936,567 4.00 24,726 12/31/18
ProQuest Investments 1,236,394 2.56 -- 9/30/18
Bain Capital Public Equity, LP 892,061 1.84 -247,883 12/31/18
Two Sigma Investments, LP 695,654 1.44 395,335 12/31/18
State Street Global Advisors (US) 661,776 1.37 109,242 12/31/18
Dimensional Fund Advisors, L.P. 645,008 1.33 -16,953 12/31/18
The Vanguard Group, Inc. 615,722 1.27 -999,720 12/31/18
Water Island Capital, LLC 568,137 1.17 568,137 2/28/19
Renaissance Technologies LLC 524,805 1.09 377,591 12/31/18
PanAgora Asset Management Inc. 482,029 1.00 97,407 12/31/18
JP Morgan Asset Management 369,800 0.76 -20,300 12/31/18
Geode Capital Management, L.L.C. 367,840 0.76 15,925 12/31/18
Abingworth Management Limited 352,300 0.73 -- 12/31/18
Northern Trust Investments, Inc. 339,386 0.70 -1,181 12/31/18
Nuveen LLC 228,084 0.47 -- 12/31/18
D. E. Shaw & Co., L.P. 205,148 0.42 103,201 12/31/18
Coleman (Lewis W) 178,000 0.37 135,000 3/28/18
PNC Capital Advisors, LLC 153,901 0.32 153,901 11/30/17
J.P. Morgan Securities LLC 150,555 0.31 145,555 12/31/18
Morgan Stanley & Co. LLC 144,052 0.30 38,803 12/31/18
BNY Mellon Asset Management 139,609 0.29 48,548 12/31/18
Guthart (Leo A) 138,225 0.29 127,500 12/31/17
OxFORD Asset Management 136,468 0.28 136,468 12/31/18
BlackRock Investment Management, LLC 116,500 0.24 -1,294 12/31/18
Algert Global LLC 92,591 0.19 77,500 12/31/18
Millennium Management LLC 80,794 0.17 70,193 12/31/18
BlackRock Financial Management, Inc. 79,220 0.16 16,149 12/31/18
Yurasov (Sergey) 72,620 0.15 -6,136 4/2/19
Wells Fargo Advisors 64,538 0.13 -69,297 12/31/18
Charles Schwab Investment Management, Inc. 62,943 0.13 -- 12/31/18
California State Teachers Retirement System 57,989 0.12 6,410 12/31/18
Goldman Sachs & Company, Inc. 55,895 0.12 -8,249 12/31/18
Bank of America Merrill Lynch (US) 46,958 0.10 16,600 12/31/18
Rhumbline Advisers Ltd. Partnership 46,946 0.10 13,660 12/31/18
Acadian Asset Management LLC 44,566 0.09 44,566 12/31/18
Bridgeway Capital Management, Inc. 42,400 0.09 -178,792 12/31/18
Mellon Investments Corporation 41,397 0.09 -- 12/31/18
GSA Capital Partners LLP 41,068 0.08 20,300 12/31/18
Brady (Stephen R) 40,786 0.08 -17,063 4/2/19
Personal Capital Advisors Corporation 37,500 0.08 13,500 12/31/18
Ter Meulen (Jan Henrik) 36,362 0.08 -14,620 4/2/19
Susquehanna International Group, LLP 35,287 0.07 35,287 12/31/18
State of Wisconsin Investment Board 35,200 0.07 23,200 12/31/18
Deutsche Asset Management Americas 33,165 0.07 -45,517 12/31/18
Paya (Carlos V) 29,500 0.06 -35,576 4/2/19
Virtu Financial BD LLC 29,460 0.06 29,460 3/31/19
Northern Trust Global Investments 27,596 0.06 5,860 12/31/18

* Insider values reflect direct beneficial ownership.

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