Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 126 198.91 94.42 45,377,556
Mutual Fund 121 36.41 18.11 8,703,609
Insider 7 2.17 0.77 372,179

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 76 83.85 44.23 21,257,871
Sellers 46 -17.79 8.34 -4,010,420
Net -- 66.07 35.89 17,247,451

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 198.91 94.42 45,377,556
Top 10 Inst. 140.63 69.23 33,272,896
Top 20 Inst. 178.96 84.77 40,737,143
Top 50 Inst. 195.92 92.91 44,652,860

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth 21 4.42 1.66 797,410
Aggressive Growth 1 0.45 0.24 115,000
Core Growth 16 1.81 0.96 459,238
Growth 4 2.16 0.46 223,172
Income 3 12.96 6.91 3,322,628
Income Value 3 12.96 6.91 3,322,628
Index 16 15.78 8.39 4,033,056
Momentum 1 -- -- 804
Other 50 144.45 71.23 34,231,812
Broker Dealer 11 1.15 0.61 295,351
GARP 9 10.28 5.48 2,634,988
Hedge Fund 23 51.45 28.40 13,650,118
Specialty 1 0.02 -- 2,220
VC/Private Equi 6 81.55 36.72 17,649,135
Value 14 1.50 0.77 371,197
Core Value 10 0.99 0.50 240,464
Deep Value 4 0.51 0.27 130,733

Top Holders

Holder Shares Held % O/S Share Change Filing Date
The Column Group LP 5,842,942 12.16 1,881,000 10/27/17
Topspin Partners, LP 5,526,514 11.50 2,428,275 12/31/17
BVF Partners L.P. 4,106,200 8.54 2,636,400 2/9/18
EcoR1 Capital, LLC 3,562,600 7.41 3,562,600 12/31/17
Bain Capital Public Equity, LP 3,316,769 6.90 2,017,756 12/31/17
Franklin Advisers, Inc. 3,231,753 6.72 2,450,000 12/31/17
Alta Partners 2,482,775 5.17 -- 4/15/17
Versant Ventures 2,208,210 4.59 -- 12/31/17
BlackRock Institutional Trust Company, N.A. 1,642,530 3.42 771,521 12/31/17
The Vanguard Group, Inc. 1,352,603 2.81 749,883 12/31/17
Bain Capital Public Equity Management, L.L.C. 1,299,013 2.70 1,299,013 9/29/17
ProQuest Investments 1,236,394 2.57 -176,886 12/31/17
Fidelity Management & Research Company 1,184,892 2.47 686,500 12/31/17
JP Morgan Asset Management 903,875 1.88 422,100 12/31/17
Svennilson Peter 800,000 1.66 -- 10/27/17
Alyeska Investment Group, L.P. 500,000 1.04 500,000 12/31/17
Marshall Wace LLP 488,933 1.02 488,933 12/31/17
PanAgora Asset Management Inc. 365,923 0.76 166,997 12/31/17
Abingworth Management Limited 352,300 0.73 -- 12/31/17
Two Sigma Investments, LP 332,917 0.69 316,441 12/31/17
Dafna Capital Management, LLC 328,500 0.68 328,500 12/31/17
Northern Trust Investments, Inc. 301,910 0.63 136,110 12/31/17
Geode Capital Management, L.L.C. 284,690 0.59 161,168 12/31/17
Acuta Capital Partners, LLC 274,100 0.57 274,100 12/31/17
State Street Global Advisors (US) 241,678 0.50 20,188 12/31/17
Granahan Investment Management, Inc. 199,000 0.41 -- 9/30/17
Weiss Multi-Strategy Advisers LLC 169,034 0.35 169,034 12/31/17
Victory Capital Management Inc. 157,119 0.33 -1,903,115 12/31/17
PNC Capital Advisors, LLC 153,901 0.32 153,901 11/30/17
Baker Bros. Advisors LP 148,937 0.31 -- 12/31/17
Guthart (Leo A) 138,225 0.29 127,500 12/31/17
Wells Fargo Advisors 134,288 0.28 -30,575 12/31/17
BlackRock Investment Management, LLC 128,638 0.27 63,220 12/31/17
Nuveen LLC 119,559 0.25 44,252 12/31/17
Bridgeway Capital Management, Inc. 115,000 0.24 -1,800 12/31/17
Moore Capital Management, LP 100,000 0.21 100,000 12/31/17
BlackRock Financial Management, Inc. 95,079 0.20 13,803 12/31/17
D. E. Shaw & Co., L.P. 95,017 0.20 84,994 12/31/17
BNY Mellon Asset Management 85,301 0.18 44,209 12/31/17
Anson Funds Management LP. 80,189 0.17 80,189 12/31/17
Baltimore (David) 78,287 0.16 -- 4/15/17
Berger (Franklin M) 75,000 0.16 50,000 10/30/17
Deutsche Asset Management Americas 72,272 0.15 43,379 12/31/17
Morgan Stanley & Co. LLC 60,035 0.12 5,992 12/31/17
Charles Schwab Investment Management, Inc. 54,543 0.11 20,400 12/31/17
California State Teachers Retirement System 50,518 0.11 22,799 12/31/17
Balyasny Asset Management LP 49,012 0.10 38,475 12/31/17
Paya (Carlos V) 43,590 0.09 38,530 1/5/18
Coleman (Lewis W) 43,000 0.09 30,000 4/15/17
Telemetry Investments, L.L.C. 39,295 0.08 39,295 12/31/17

* Insider values reflect direct beneficial ownership.

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