Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 101 95.30 97.30 46,862,352
Mutual Fund 110 5.93 7.83 3,770,959
Insider 7 1.85 1.18 567,981

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 47 19.97 28.15 13,557,849
Sellers 62 -5.50 8.07 -3,887,104
Net -- 14.47 20.08 9,670,745

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 95.30 97.30 46,862,352
Top 10 Inst. 82.28 79.92 38,495,204
Top 20 Inst. 88.85 90.42 43,549,524
Top 50 Inst. 94.49 96.21 46,340,821

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth 16 1.34 2.10 1,011,048
Aggressive Growth 1 0.06 0.09 42,400
Core Growth 13 1.25 1.96 944,126
Growth 2 0.04 0.05 24,522
Income 1 0.18 0.29 139,609
Income Value 1 0.18 0.29 139,609
Index 16 5.46 8.62 4,153,188
Other 37 76.55 69.98 33,704,748
Broker Dealer 10 0.65 1.04 503,190
GARP 7 1.95 2.33 1,122,333
Hedge Fund 13 17.54 28.00 13,487,289
Specialty 1 0.01 0.01 4,576
VC/Private Equi 6 56.40 38.59 18,587,360
Value 9 0.96 0.79 381,194
Core Value 6 0.75 0.45 218,310
Deep Value 3 0.21 0.34 162,884

Top Holders

Holder Shares Held % O/S Share Change Filing Date
The Column Group LP 6,642,942 13.79 800,000 3/28/18
The Column Group Management LP 6,642,942 13.79 6,642,942 12/31/18
Topspin Partners, LP 5,664,739 11.76 138,225 3/28/18
EcoR1 Capital, LLC 5,603,191 11.63 3,361,291 12/31/18
BVF Partners L.P. 5,185,383 10.77 527,030 12/31/18
Alta Partners 2,482,775 5.15 -- 3/28/18
Versant Ventures 2,208,210 4.58 -- 12/31/18
BlackRock Institutional Trust Company, N.A. 1,936,567 4.02 24,726 12/31/18
ProQuest Investments 1,236,394 2.57 -- 9/30/18
Bain Capital Public Equity, LP 892,061 1.85 -247,883 12/31/18
Two Sigma Investments, LP 695,654 1.44 395,335 12/31/18
State Street Global Advisors (US) 661,776 1.37 109,242 12/31/18
Dimensional Fund Advisors, L.P. 645,008 1.34 -16,953 12/31/18
The Vanguard Group, Inc. 615,722 1.28 -999,720 12/31/18
Renaissance Technologies LLC 524,805 1.09 377,591 12/31/18
PanAgora Asset Management Inc. 482,029 1.00 97,407 12/31/18
JP Morgan Asset Management 369,800 0.77 -20,300 12/31/18
Geode Capital Management, L.L.C. 367,840 0.76 15,925 12/31/18
Abingworth Management Limited 352,300 0.73 -- 12/31/18
Northern Trust Investments, Inc. 339,386 0.70 -1,181 12/31/18
Nuveen LLC 228,084 0.47 -4,259 9/30/18
D. E. Shaw & Co., L.P. 205,148 0.43 103,201 12/31/18
Coleman (Lewis W) 178,000 0.37 135,000 3/28/18
PNC Capital Advisors, LLC 153,901 0.32 153,901 11/30/17
J.P. Morgan Securities LLC 150,555 0.31 145,555 12/31/18
Morgan Stanley & Co. LLC 144,052 0.30 38,803 12/31/18
BNY Mellon Asset Management 139,609 0.29 48,548 12/31/18
Guthart (Leo A) 138,225 0.29 127,500 12/31/17
OxFORD Asset Management 136,468 0.28 136,468 12/31/18
BlackRock Investment Management, LLC 116,500 0.24 -1,294 12/31/18
Algert Global LLC 92,591 0.19 77,500 12/31/18
Millennium Management LLC 80,794 0.17 70,193 12/31/18
BlackRock Financial Management, Inc. 79,220 0.16 16,149 12/31/18
Yurasov (Sergey) 78,756 0.16 21,478 1/7/19
Baltimore (David) 78,287 0.16 -- 3/28/18
Berger (Franklin M) 75,000 0.16 50,000 3/28/18
Paya (Carlos V) 65,076 0.14 49,986 1/7/19
Wells Fargo Advisors 64,538 0.13 -69,297 12/31/18
Charles Schwab Investment Management, Inc. 62,943 0.13 -- 12/31/18
California State Teachers Retirement System 57,989 0.12 6,410 12/31/18
Brady (Stephen R) 57,849 0.12 19,484 1/7/19
Goldman Sachs & Company, Inc. 55,895 0.12 -8,249 12/31/18
Ter Meulen (Jan Henrik) 50,982 0.11 21,586 1/7/19
Bank of America Merrill Lynch (US) 46,958 0.10 16,600 12/31/18
Rhumbline Advisers Ltd. Partnership 46,946 0.10 13,660 12/31/18
Acadian Asset Management LLC 44,566 0.09 44,566 12/31/18
Bridgeway Capital Management, Inc. 42,400 0.09 -178,792 12/31/18
Mellon Investments Corporation 41,397 0.09 -- 12/31/18
GSA Capital Partners LLP 41,068 0.09 20,300 12/31/18
Personal Capital Advisors Corporation 37,500 0.08 13,500 12/31/18

* Insider values reflect direct beneficial ownership.

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