Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 118 132.58 83.21 40,044,325
Mutual Fund 109 23.02 11.78 5,667,147
Insider 7 2.17 0.77 372,179

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 55 20.02 12.44 5,985,515
Sellers 57 -26.78 16.29 -7,840,962
Net -- -6.76 3.85 -1,855,447

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 132.58 83.21 40,044,325
Top 10 Inst. 104.75 65.96 31,742,868
Top 20 Inst. 120.67 75.98 36,566,853
Top 50 Inst. 130.53 82.06 39,491,660

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth 20 2.15 1.34 645,416
Aggressive Growth 1 0.56 0.35 170,000
Core Growth 16 1.51 0.94 452,346
Growth 3 0.08 0.05 23,070
Income 2 0.29 0.19 89,241
Income Value 2 0.29 0.19 89,241
Index 16 14.91 9.34 4,496,530
Other 46 111.24 70.00 33,686,510
Broker Dealer 13 1.18 0.74 358,258
GARP 9 8.66 5.45 2,624,280
Hedge Fund 17 40.04 25.17 12,112,036
Specialty 1 0.01 0.01 4,576
VC/Private Equi 6 61.34 38.62 18,587,360
Value 13 1.36 0.75 359,691
Core Value 9 0.97 0.50 241,960
Deep Value 4 0.39 0.24 117,731

Top Holders

Holder Shares Held % O/S Share Change Filing Date
The Column Group LP 6,642,942 13.80 800,000 3/28/18
Topspin Partners, LP 5,664,739 11.77 138,225 3/28/18
EcoR1 Capital, LLC 4,437,600 9.22 875,000 3/31/18
BVF Partners L.P. 4,106,200 8.53 2,636,400 3/31/18
Alta Partners 2,482,775 5.16 -- 3/28/18
Versant Ventures 2,208,210 4.59 -- 3/31/18
BlackRock Institutional Trust Company, N.A. 1,712,118 3.56 69,588 3/31/18
Bain Capital Public Equity, LP 1,680,987 3.49 -1,635,782 3/31/18
The Vanguard Group, Inc. 1,570,903 3.26 218,300 3/31/18
ProQuest Investments 1,236,394 2.57 -- 3/31/18
Fidelity Management & Research Company 1,184,492 2.46 -400 3/31/18
JP Morgan Asset Management 830,675 1.73 -73,200 3/31/18
Alyeska Investment Group, L.P. 452,516 0.94 -47,484 3/31/18
PanAgora Asset Management Inc. 393,947 0.82 28,024 3/31/18
State Street Global Advisors (US) 392,833 0.82 151,155 3/31/18
Abingworth Management Limited 352,300 0.73 -- 3/31/18
Dafna Capital Management, LLC 328,500 0.68 -- 3/31/18
Northern Trust Investments, Inc. 302,081 0.63 171 3/31/18
Two Sigma Investments, LP 299,610 0.62 -33,307 3/31/18
Geode Capital Management, L.L.C. 287,031 0.60 2,341 3/31/18
Telemetry Investments, L.L.C. 248,800 0.52 209,505 3/31/18
Dimensional Fund Advisors, L.P. 192,330 0.40 157,784 3/31/18
Coleman (Lewis W) 178,000 0.37 135,000 3/28/18
Bridgeway Capital Management, Inc. 170,000 0.35 55,000 3/31/18
Stonepine Capital Management, LLC 161,226 0.34 161,226 3/31/18
Marshall Wace LLP 155,864 0.32 -333,069 3/31/18
PNC Capital Advisors, LLC 153,901 0.32 153,901 11/30/17
Baker Bros. Advisors LP 148,937 0.31 -- 3/31/18
Nuveen LLC 148,503 0.31 28,944 3/31/18
Wells Fargo Advisors 139,926 0.29 5,638 3/31/18
Guthart (Leo A) 138,225 0.29 127,500 12/31/17
BlackRock Investment Management, LLC 114,840 0.24 -13,798 3/31/18
BlackRock Financial Management, Inc. 88,311 0.18 -6,768 3/31/18
BNY Mellon Asset Management 81,546 0.17 -3,755 3/31/18
Weiss Multi-Strategy Advisers LLC 80,000 0.17 -89,034 3/31/18
Baltimore (David) 78,287 0.16 -- 3/28/18
Berger (Franklin M) 75,000 0.16 -- 3/28/18
Morgan Stanley & Co. LLC 63,535 0.13 3,500 3/31/18
Balyasny Asset Management LP 60,812 0.13 11,800 3/31/18
Charles Schwab Investment Management, Inc. 54,543 0.11 -- 3/31/18
Susquehanna Financial Group, LLLP 51,654 0.11 23,422 3/31/18
Jacobs Levy Equity Management, Inc. 50,933 0.11 50,933 3/31/18
California State Teachers Retirement System 50,518 0.10 -- 3/31/18
BNY Mellon Asset Management North America Corporation 41,890 0.09 5,118 3/31/18
Virtu Americas LLC 37,772 0.08 37,772 3/31/18
DRW Securities, LLC 37,000 0.08 20,000 3/31/18
T. Rowe Price Associates, Inc. 35,010 0.07 62 3/31/18
Deutsche Asset Management Americas 34,256 0.07 -38,016 3/31/18
Yurasov (Sergey) 27,325 0.06 27,325 1/5/18
Rhumbline Advisers Ltd. Partnership 25,863 0.05 9,465 3/31/18

* Insider values reflect direct beneficial ownership.

Copyright Thomson Reuters Corporation