Ownership Profile

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 120 160.23 81.85 39,420,990
Mutual Fund 113 23.72 11.91 5,738,655
Insider 7 2.17 0.77 372,179

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 63 12.18 6.11 2,943,935
Sellers 55 -23.99 13.19 -6,351,941
Net -- -11.81 7.08 -3,408,006

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 160.23 81.85 39,420,990
Top 10 Inst. 125.04 65.49 31,544,646
Top 20 Inst. 146.42 75.25 36,243,271
Top 50 Inst. 157.39 80.52 38,780,647

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth 16 3.87 1.76 849,605
Aggressive Growth 2 0.56 0.26 123,471
Core Growth 11 3.19 1.46 701,594
Growth 3 0.12 0.05 24,540
Income 3 0.86 0.39 189,414
Income Value 2 0.54 0.25 119,579
Yield 1 0.32 0.14 69,835
Index 16 22.15 10.12 4,874,413
Other 47 129.06 67.31 32,418,755
Broker Dealer 10 1.47 0.67 322,781
GARP 10 10.45 4.77 2,297,081
Hedge Fund 20 51.03 23.27 11,206,957
Specialty 1 0.02 0.01 4,576
VC/Private Equi 6 66.08 38.59 18,587,360
Value 9 1.39 0.67 321,388
Core Value 7 0.86 0.42 203,971
Deep Value 2 0.53 0.24 117,417

Top Holders

Holder Shares Held % O/S Share Change Filing Date
The Column Group LP 6,642,942 13.79 800,000 3/28/18
Topspin Partners, LP 5,664,739 11.76 138,225 3/28/18
EcoR1 Capital, LLC 4,437,600 9.21 -- 6/30/18
BVF Partners L.P. 4,158,353 8.63 52,153 6/30/18
Alta Partners 2,482,775 5.15 -- 3/28/18
Versant Ventures 2,208,210 4.58 -- 6/30/18
BlackRock Institutional Trust Company, N.A. 1,887,829 3.92 175,711 6/30/18
The Vanguard Group, Inc. 1,604,436 3.33 33,533 6/30/18
ProQuest Investments 1,236,394 2.57 -- 6/30/18
Bain Capital Public Equity, LP 1,221,368 2.54 -459,619 6/30/18
Fidelity Management & Research Company 1,184,492 2.46 -- 6/30/18
State Street Global Advisors (US) 466,159 0.97 73,326 6/30/18
Dimensional Fund Advisors, L.P. 447,026 0.93 254,696 6/30/18
Portolan Capital Management, L.L.C. 444,875 0.92 444,875 6/30/18
PanAgora Asset Management Inc. 408,067 0.85 14,120 6/30/18
JP Morgan Asset Management 396,000 0.82 -434,675 6/30/18
Abingworth Management Limited 352,300 0.73 -- 6/30/18
Northern Trust Investments, Inc. 336,735 0.70 34,654 6/30/18
Geode Capital Management, L.L.C. 334,471 0.69 47,440 6/30/18
Dafna Capital Management, LLC 328,500 0.68 -- 6/30/18
Two Sigma Investments, LP 257,514 0.53 -42,096 6/30/18
Nuveen LLC 232,343 0.48 83,840 6/30/18
Coleman (Lewis W) 178,000 0.37 135,000 3/28/18
PNC Capital Advisors, LLC 153,901 0.32 153,901 11/30/17
Guthart (Leo A) 138,225 0.29 127,500 12/31/17
Wells Fargo Advisors 137,282 0.29 -2,644 6/30/18
BlackRock Financial Management, Inc. 116,798 0.24 28,487 6/30/18
BlackRock Investment Management, LLC 116,183 0.24 1,343 6/30/18
Telemetry Investments, L.L.C. 113,500 0.24 -135,300 6/30/18
BNY Mellon Asset Management 84,188 0.17 2,642 6/30/18
Bridgeway Capital Management, Inc. 81,292 0.17 -88,708 6/30/18
Baltimore (David) 78,287 0.16 -- 3/28/18
Berger (Franklin M) 75,000 0.16 -- 3/28/18
Morgan Stanley & Co. LLC 72,577 0.15 9,042 6/30/18
Alps Advisors, Inc. 69,835 0.14 69,835 6/30/18
DRW Securities, LLC 58,900 0.12 21,900 6/30/18
Charles Schwab Investment Management, Inc. 54,443 0.11 -100 6/30/18
Deutsche Asset Management Americas 53,449 0.11 19,193 6/30/18
California State Teachers Retirement System 51,579 0.11 1,061 6/30/18
Bank of America Merrill Lynch (US) 46,754 0.10 32,669 6/30/18
Essex Investment Management Company, LLC 42,179 0.09 42,179 6/30/18
BNY Mellon Asset Management North America Corporation 41,397 0.09 -493 6/30/18
Goldman Sachs & Company, Inc. 39,585 0.08 20,863 6/30/18
Tiverton Asset Management LLC 38,675 0.08 38,675 6/30/18
Citadel LLC 36,159 0.08 36,159 6/30/18
Crow Point Partners, LLC 35,391 0.07 27,696 6/30/18
T. Rowe Price Associates, Inc. 35,045 0.07 35 6/30/18
Rhumbline Advisers Ltd. Partnership 33,511 0.07 7,648 6/30/18
A.R.T. Advisors, LLC 33,067 0.07 33,067 6/30/18
Boothbay Fund Management, LLC 32,317 0.07 32,317 6/30/18

* Insider values reflect direct beneficial ownership.

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